Decoding Amygdala Hyperactivity: A Neurological Perspective
Amygdala hyperactivity means the amygdala, a key part of the brain’s limbic system, is more active than usual. This neurological state is often linked to bigger emotional responses, especially fear, anxiety and stress. From a neuro perspective understanding amygdala hyperactivity means looking at the complex interplay of neural circuits, neurotransmitter systems and regulatory mechanisms that control its function. Clinically an overactive amygdala can manifest as a range of emotional and behavioural dysfunctionalities, so diagnosis and targeted interventions are crucial.

The amygdala is deep in the temporal lobes and is responsible for processing sensory information and adding emotional meaning to it. It gets input from various brain regions including the sensory cortices, hippocampus and prefrontal cortex so it can integrate contextual info and produce the right emotional response. In people with amygdala hyperactivity this whole system gets disrupted and they have an exaggerated or inappropriate emotional response to a stimulus that would normally evoke a more muted response.
One key to understanding amygdala hyperactivity is understanding its relationship with the autonomic nervous system (ANS). The amygdala is linked to the ANS which controls involuntary functions like heart rate, blood pressure and respiration. When the amygdala detects a threat it triggers a physiological response via the hypothalamus leading to the activation of the flight or freeze responses. In PTSD, some individuals may become stuck in a persistent state of hyperarousal (fight/flight) or hypoarousal (freeze/dissociation) underpinned by amygdala hyperactivity and impaired PFC regulation.
The Amygdala’s Role in Emotional Processing and Memory Formation
The amygdala’s role goes way beyond just detecting threats. It’s also involved in emotional learning, memory consolidation and social cognition. Understanding these functions is key to understanding the impact of amygdala hyperactivity on mental health.
In terms of emotional processing, the amygdala, along with the prefrontal cortex, hippocampus and insula, contribute to assigning emotional significance to sensory experiences. For example, these regions can help associate a sound or image with fear or pleasure. This is important for adaptive behaviour so we can quickly recognise and respond to dangers or opportunities in our environment. But in people with amygdala hyperactivity this tagging can get skewed and we focus too much on the negative or threatening stimuli.
The amygdala also plays a big role in memory formation, especially in the consolidation of emotionally salient memories. When an emotionally charged event happens the amygdala enhances the encoding and storage of the memory making it more vivid and accessible in the future. This is thought to be important for learning from past experiences and adapting to future challenges. But in cases of trauma or chronic stress the amygdala hyperactivity can create intrusive, emotionally charged memories that contribute to conditions like PTSD.
Unpacking the Aetiology: Causes and Contributing Factors

Several things can contribute to amygdala hyperactivity. These are genetic predispositions, early life experiences, environmental influences and chronic stress. Understanding these factors is key to targeted prevention and intervention.
Genetic factors shape individual differences in amygdala structure and function. Studies have shown that variations in genes involved in neurotransmitter signalling (e.g. serotonin and dopamine) can impact amygdala reactivity and emotional regulation. Some people may be more prone to amygdala hyperactivity in response to environmental stressors with certain genetic variations.
Early life experiences, especially traumatic or chronic stress during childhood, can have a big impact on brain development including the amygdala. Adverse childhood experiences (ACEs) such as abuse, neglect or exposure to violence can sensitise the amygdala making it more reactive to future stressors. This sensitisation can lead to chronic amygdala hyperactivity and anxiety disorders or PTSD.
Amygdala Hyperactivity and Trauma: The Feedback Loop
Trauma and amygdala hyperactivity is a complex and often self-perpetuating relationship. Traumatic experiences can trigger a cascade of neurobiological changes that leads to chronic amygdala hyperactivity which in turn can exacerbate the symptoms of trauma. This creates a feedback loop that can be hard to break without targeted intervention.
When someone experiences a traumatic event, the amygdala activates the hypothalamic-pituitary-adrenal (HPA) axis, triggering the release of stress hormones such as cortisol and adrenaline that can initiate the fight, flight or freeze response. In cases of chronic stress or trauma, this heightened activation can persist and lead to sustained amygdala hyperactivity and prolonged stress responses. The sensitised amygdala then becomes more easily triggered by reminders of the trauma and leads to exaggerated emotional responses like anxiety, fear and flashbacks.
Comorbid Conditions: Anxiety Disorders, PTSD, and Beyond
In PTSD and anxiety disorders, amygdala hyperactivity is often accompanied by reduced prefrontal cortex (PFC) regulation, impairing the brain’s ability to appropriately modulate fear responses, contributing to symptoms such as hypervigilance, and exaggerated threat perception.
Similar dysregulation is also implicated in depression, borderline personality disorder (BPD), and anxiety disorders such as generalised anxiety disorder (GAD) where heightened emotional reactivity and difficulties with emotional regulation are key features.
In PTSD the dysregulation involving amygdala hyperactivity and PFC impairment plays a central role in the development of intrusive memories, flashbacks and hyperarousal symptoms. The traumatic event sensitises the amygdala making it more reactive to trauma related cues. This leads to intense emotional distress and avoidance behaviours that severely impair daily living.
Neuroimaging Techniques: Seeing Amygdala Activity
Neuroimaging studies using functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) have given us a window into the neural mechanisms of amygdala hyperactivity. These techniques allow researchers to see brain activity in real time.
fMRI is particularly useful for studying amygdala activity because it has high spatial resolution and can pinpoint the specific brain regions that are active during different emotional states. Neuroimaging studies using fMRI have shown that individuals with anxiety disorders and PTSD have heightened amygdala activation in response to threat-related stimuli compared to healthy controls, particularly when prefrontal regulatory mechanisms are impaired.
These techniques can also be used to measure the effectiveness of different interventions in modulating amygdala activity.
Therapeutic Interventions: Targeting Amygdala Function
Several interventions have been developed to target amygdala function and calm it down. These interventions mainly focus on helping people to regulate their emotions, reduce avoidance and process traumatic memories.
Cognitive Behavioural Therapy (CBT) is a common approach that aims to change maladaptive thinking and behaviours that contribute to anxiety and distress. By identifying and challenging negative thoughts, people can reframe their experience and reduce the intensity of their emotions. CBT techniques like exposure therapy can also help people face their feared stimuli in a safe and controlled environment, gradually reducing their anxiety and avoidance.
Trauma-focused Cognitive Behavioural Therapy (TF-CBT), Cognitive Processing Therapy and Prolonged Exposure Therapy are interventions designed to process traumatic memories and reduce PTSD symptoms. These therapies help people confront and process the traumatic event in a safe and supportive environment, so they can integrate the experience and reduce its emotional impact.
Eye Movement Desensitisation and Reprocessing (EMDR) is another therapy that has been shown to be effective for trauma. EMDR involves having people recall the traumatic event while doing bilateral stimulation, such as eye movements or tapping. This is thought to help reprocess the traumatic memory and reduce its emotional intensity.
The Biopsychosocial Model: A Holistic Approach
A biopsychosocial approach acknowledges amygdala hyperactivity is influenced by a mix of biological, psychological and social factors. Understanding and addressing these factors in full is key to treatment.
Biological factors like genetics, neurochemistry and brain structure can impact amygdala function and vulnerability to emotional disorders. Psychological factors like cognitive biases, emotional regulation skills and coping strategies can also affect amygdala reactivity and emotional well-being. Social factors like social support, relationships and environmental stressors can impact amygdala function and overall mental health.
By addressing all three, clinicians can develop a treatment plan that’s tailored to the individual.
Future Directions: Research and Novel Treatment Strategies
More research is being done to find new ways to assess and target amygdala function and help people with emotional disorders. This includes developing pharmaceuticals that can directly affect amygdala, and the consideration of neuronal modulation for the treatment of maladaptive disorders.
Advanced neuromodulation techniques like Transcranial Magnetic Stimulation (TMS) and Deep Brain Stimulation (DBS).TMS involves using magnetic pulses to stimulate or stop activity in specific brain areas. Current TMS has been explored as a treatment for anxiety and depression by targeting the dorsolateral prefrontal cortex, which regulates amygdala activity. By enhancing prefrontal inhibitory control, TMS can indirectly reduce amygdala hyperactivation and emotional hyperreactivity. DBS involves implanting electrodes in the brain to deliver electrical stimulation to specific brain areas. This has been used to treat severe cases of treatment-resistant obsessive compulsive disorder (OCD), Parkinson’s disease, and major depressive disorder (MDD) While DBS does not directly target amygdala hyperactivity, research is exploring its potential in modulating limbic circuits for trauma-related disorders.
The field of affective neuroscience is also helping us understand the neural mechanisms of emotional processing and regulation. With advanced neuroimaging techniques researchers are figuring out the dynamic interplay of brain areas involved in emotion and that will lead to more targeted and effective interventions.
Reviewed by: Dr. Emma Bardsley

Dr Emma Bardsley is a neuroscientist with a PhD from Oxford and a post doctorate from Auckland University, along with an undergraduate degree in Pharmacology from King’s College London. She has lectured extensively on neuroscience, physiology, and pharmacological interventions, bridging foundational research and its clinical applications. With a strong record of publications in high-impact journals and extensive experience in scientific writing, editing, and peer review, she excels at translating complex research into practical insights. Based in New Zealand and collaborating internationally, Emma is dedicated to advancing understanding and treatment in the fields of trauma, addiction, and recovery.
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