Dependence: Unpacking the Neuroscience of Compulsive Behaviours
Addiction is a complicated condition influenced by neurological, psychological and social factors that leads to compulsive behaviour or substance use despite negative consequences. It’s a state where an individual’s functioning becomes tied to a substance or activity and often to the detriment of their overall well-being. This article will explore the different facets of addiction, and look at the evidence based ways to manage it.
Understanding Addiction: A Biopsychosocial Perspective

The biopsychosocial model provides the framework for understanding addiction. According to this model, addiction arises from the interaction of biological (e.g. genetics, neurochemistry), psychological (e.g. trauma, coping mechanisms) and social factors (e.g. environment, cultural norms).
- Biological Factors: Genetic predispositions can make you more vulnerable to addiction. Repeated exposure to substances or engaging in certain activities can change the structure and function of the brain, particularly in the reward pathways.
- Psychological Factors: People with a history of trauma, or those who struggle with emotional regulation, may be more likely to develop addiction as a way of coping with distress. Cognitive biases and maladaptive beliefs can also play a big role.
- Social Factors: The environment you live in, including exposure to substance use, social norms and peer influence can impact the likelihood of addiction.
The Role of Dopamine in the Development of Dependence
Dopamine, the reward and motivation neurotransmitter, is central to development and maintenance of addiction. It was once thought that dopamine was responsible for the pleasure associated with reinforcers, but more recent research shows it’s more complicated.
Dopamine is released not only after a rewarding experience but also in anticipation of it, reinforcing learned associations that drive compulsive seeking behaviours . This anticipatory dopamine release is key to understanding addiction. As the brain gets used to a substance or activity, dopamine is released in response to cues associated with that substance or activity and we become driven to seek it out. Over time this can lead to a situation where we end up with intense cravings and compulsive behaviour even when there’s no actual reward). The reward anticipation becomes so linked to dopamine release that we may seek out the substance or activity just to alleviate the discomfort of withdrawal or craving rather than for pleasure.
Trauma and Dependence: Exploring the Link

The relationship between trauma and dependence is well established. Trauma, especially in early life, can disrupt the development of healthy coping mechanisms and emotional regulation skills. People who have experienced trauma may turn to substances or activities to self-medicate and escape from painful emotions or memories Also trauma can change the brain, making people more vulnerable to dependence. For example trauma can impair the prefrontal cortex, the part of the brain that deals with executive functions like impulse control and decision making. This can make it harder for people to resist cravings and make rational decisions about substance use or other addictions.
The Four “M”s of Brain Reward: Memory, Motivation, Movement, and Meaning
A useful way to think about “brain reward” is to break it down into four components, the four “M”s:
- Memory: Rewarding experiences create strong memories that are easily recalled and associated with positive emotions.
- Motivation: Rewarding experiences motivate us to chase those experiences again, even in the face of obstacles.
- Movement: Rewarding experiences often involve physical action or movement towards a specific goal.
- Meaning: Rewarding experiences are meaningful to the individual, providing a sense of purpose, satisfaction or accomplishment.
Any substance or activity that can activate the brain’s reward system involves all four “M”s. For example, gambling creates positive memories of past wins, motivates people to keep playing in the hope of future wins, involves physical action like placing bets, and provides a sense of excitement and purpose, even if temporary.
Recognising the Signs and Symptoms of Dependence
Identifying the signs and symptoms is key to early intervention and support. These signs and symptoms will vary depending on the substance or activity but some common ones are:
- Tolerance: Needing more and more of the substance or activity to get the same effect.
- Withdrawal: Feeling nausea, anxiety or irritability when the substance or activity is reduced or stopped.
- Craving: Feeling intense urges or desires for the substance or activity.
- Loss of control: Unable to control the amount or frequency of substance use or the activity.
- Neglect of responsibilities: Neglecting work, school or family responsibilities because of the substance or the activity.
- Continuing to use despite negative consequences: Continuing to use the substance or activity despite the negative consequences such as health problems, relationship issues or financial problems.
Differentiating Dependence from Addiction and Abuse

While the terms dependence, addiction and abuse are used interchangeably, they have different meanings.
- Abuse is the misuse of a substance or behaviour that causes harm.
- Dependence refers to the physical or psychological adaptation to a substance or behaviour, characterised by tolerance and withdrawal.
- Addiction describes the compulsive use of a substance or engagement in a behaviour despite negative consequences behaviour despite the harm. It includes dependence and loss of control.
A person can be dependent on a substance (e.g. prescription opioids for pain management) without exhibiting the compulsive behaviours characteristic of addiction.
Evidence-Based Therapeutic Approaches for Addressing Dependence
Addressing addiction requires a holistic approach that targets the biological, psychological and social factors. Several evidence based therapies have been proven to help individuals manage addiction and achieve long term recovery. At Highlands Recovery we offer:
- Cognitive Behavioural Therapy (CBT): CBT helps individuals identify and change negative thoughts and behaviours that contribute to addiction. Clients learn coping strategies to manage cravings, identify triggers and navigate high risk situations to prevent relapse.Eye Movement Desensitisation and Reprocessing (EMDR): EMDR is a therapy technique to reduce the distress associated with traumatic memories. It involves focusing on a traumatic memory while undergoing bilateral stimulation, such as eye movements, which can process the memory and reduce its emotional impact.
- Prolonged Exposure Therapy: Prolonged Exposure is used primarily for PTSD. It involves gradually exposing the individual to trauma related memories, feelings and situations in a safe and controlled environment. The goal is to help the individual process the trauma and reduce the anxiety and fear.
- Trauma focused Cognitive Behavioural Therapy (TF-CBT): TF-CBT combines CBT with trauma sensitive strategies to address the specific needs of individuals who have experienced trauma. It helps clients process traumatic experiences, develop coping skills and manage emotional regulation.
- Cognitive Processing Therapy (CPT): CPT is another type of trauma focused therapy that helps individuals challenge and change negative thoughts and beliefs about the trauma and its aftermath. It involves examining the impact of the trauma on beliefs about safety, trust, power, control and intimacy.
Building Self-Reliance: Long-Term Strategies for Managing Dependence
Sustained recovery from addiction means building self reliance and healthy coping mechanisms. This includes:
- A Strong Support System: Connecting with supportive friends, family or a support group can give you a sense of belonging and reduce feelings of isolation.
- Self Care: Engaging in activities that promote physical and emotional well being, like exercise, healthy eating and mindfulness can help manage stress and prevent relapse.
- Realistic Goals: Setting achievable goals and celebrating small wins can boost confidence and motivation.
- Relapse Prevention Skills: Identifying triggers, developing coping strategies and creating a relapse prevention plan can help you stay on track with your recovery.
Remember recovery is a process not an event. There will be bumps along the way. With the right support and strategies individuals can effectively manage addiction, building a fulfilling sustainable life in recovery.
Highlands Recovery, located near Sydney in Australia, offers a fully controlled, intensive residential program incorporating individual and group therapy, diet, yoga, meditation, personal training, massage, sauna and ice baths. Highlands Recovery’s aftercare program offers ongoing support with weekly individual and group virtual therapy sessions and regular well being check ins. This allows for a gentle “step down” from residential care, making the transition back to everyday life smooth.
Reviewed by: Dr. Emma Bardsley

Dr Emma Bardsley is a neuroscientist with a PhD from Oxford and a post doctorate from Auckland University, along with an undergraduate degree in Pharmacology from King’s College London. She has lectured extensively on neuroscience, physiology, and pharmacological interventions, bridging foundational research and its clinical applications. With a strong record of publications in high-impact journals and extensive experience in scientific writing, editing, and peer review, she excels at translating complex research into practical insights. Based in New Zealand and collaborating internationally, Emma is dedicated to advancing understanding and treatment in the fields of trauma, addiction, and recovery.
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