Signs and Symptoms of Prefrontal Cortex Dysfunction

The frontal lobe, at the front of the brain, is key to higher level thinking. When this area goes wrong it can cause dysexecutive syndrome, a condition that describes a cluster of symptoms that can be broadly categorised into cognitive, emotional and behavioural impairments that lead to deficits in executive function. Please note that while these categories provide a framework for understanding prefrontal cortex dysfunction, individual experiences can be hugely varied with some people displaying more of one type of symptom than others.
Movement
- Apraxia: Difficulty in planning and executing voluntary movements,even when strength and coordination is intact. This can affect everyday tasks like dressing or using utensils.
- Gait abnormality: Irregular walking patterns, shuffling or instability.
Emotional
- Difficulty regulating emotions: Impulsive and can’t control emotional responses like anger, excitement or sadness.
- Depression: Feeling sad, hopeless and loss of interest in activities and maybe changes in sleep, appetite and energy levels.
Hard to understand others: Impaired ability to interpret social cues, emotions or understand the intentions behind others’ thoughts and feelings, leading to social difficulties and misunderstandings.
Cognitive
- Utilisation behaviour: Impulsive tendency to interact with objects in the environment, even if it’s not relevant to the situation.
- Perseveration behaviour: Persistent repetitive. Repeating actions, thoughts or words even when not necessary or appropriate. Can display difficulty switching between tasks, or getting stuck on an idea, or repetition.
- Attention deficits: Difficulty focussing on a task, and high distractibility.
- Disorganised thinking: Limited logical thought processes, that can result in difficulties following conversations or lack of coherency.
Behavioural
- Social disinhibition: Impaired ability to control socially inappropriate behaviour, impulsive, rude or disregard for social norms.
- Compulsive eating: Overwhelming urge to eat, often resulting in overeating and weight gain.
Language
- Aphasia: Language impairment, difficulty to communicate effectively, speaking, writing or understanding language
- Anomia: Difficulty recalling words, leading to pauses in speech.
Unpacking Dysexecutive Syndrome
Dysexecutive syndrome is a complex cluster of symptoms that often co-occur and suggest an executive function disturbance in the prefrontal cortex. But we need to recognise the variability in how this manifests; not everyone will have the same combination of symptoms. This variability has led some researchers to question whether dysexecutive syndrome is a useful diagnostic category and instead suggest we look at the specific executive function deficits in each individual. Advancements in neuroimaging techniques have helped to identify the precise neural circuits that underpin impaired executive function, with recent research highlighting the importance of several distributed networks in executive control, rather than a reliance on the PFC alone.
Anatomical Regions and Specific Impairments
The frontal lobe is divided into distinct anatomical regions:
- Precentral gyrus (primary motor cortex): This area is responsible for planning, initiation and execution of voluntary movements. Damage to this area will result in motor deficits like weakness or paralysis.
- Dorsolateral PFC (DLPFC): Involved in higher order cognitive processes like working memory, planning, decision making and cognitive flexibility. The left hemisphere is for verbal memory and the right hemisphere for spatial memory. Lesions to the DLPFC will result in problem solving difficulties, attentional difficulties and disorganised thinking and behaviour.
- Left frontal operculum (Broca’s area): Primarily responsible for expressive language production, so for formulating and articulating sentences. Damage to Broca’s area will result in expressive aphasia, inability to speak fluently and form grammatically correct sentences.
- Orbitofrontal cortex (OFC): Regulates emotions, impulses and social behaviour. It contributes to decision making by integrating emotional information and guiding behaviour according to social norms. Damage to the OFC will result in impulsivity, disinhibition and poor social judgment.
Aetiology: Causes and Risk Factors
Frontal lobe dysfunction can arise from:
- Traumatic brain injury (TBI): Head injuries, often from accidents or falls, can damage the frontal lobe, especially the orbitofrontal cortex since it’s near the base of the skull.
- Cerebrovascular disease: Stroke, from a blockage of blood flow to the brain, can damage the frontal lobe and cause cognitive and motor issues.
- Brain tumours: Tumours like meningiomas, which come from the membranes surrounding the brain, can compress or invade the frontal lobe and disrupt its function.
- Neurodegenerative diseases: Alzheimer’s disease and frontotemporal dementia (FTD) are neurodegenerative conditions that can affect the frontal lobe specifically and cause progressive cognitive and behavioural decline. FTD is characterised by atrophy of the frontal and temporal lobes and changes in personality, behaviour and language.
The Prefrontal Cortex in ADHD

Attention-deficit hyperactivity disorder (ADHD) is linked to prefrontal cortex dysfunction. Neuroimaging studies have shown structural and functional differences in the PFC of individuals with ADHD. The prefrontal association cortex, describes a network of interconnected brain regions responsible for regulating attention, impulse control and emotional regulation, that are commonly impaired in ADHD symptoms.
Stress-induced Prefrontal Cortex Dysfunction
The prefrontal cortex is highly sensitive to chronic stress. While mild stress can have a temporary impact on cognitive functions mediated by the PFC, these effects cease when the stressor has been mitigated. . Chronic stress, however, can cause structural alterations in the PFC, including dendritic atrophy and decreased synaptic connectivity, leading to weakened PFC function, impaired cognition, and increased susceptibility to mental health disorders
Diagnostic Tools and Assessment
A full assessment is required to diagnose frontal lobe dysfunction:
- Neurological examination: To check motor and sensory functions, reflexes and cranial nerves.
- Neuropsychological tests: To test cognitive functions including attention, memory, language, executive functions and visuospatial skills.
- Brain imaging: CT scans, MRI and PET scans to visualise brain structure and identify any lesions in the frontal lobe.
Executive Function and Distributed Processes
Executive function which regulates cognition, emotion and behaviour, depends on an integration of signals within the PFC, which facilitate goal-directed actions in response to sensory input, and emotional feedback. Prefrontal cortex areas are involved in social, emotional and motivational aspects of behaviour.
Clinical Presentation of Lesions
The information provided in this article is for educational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment of any medical condition.
Highlands Recovery recognises the complexity of neuro conditions and the importance of understanding brain function to address various challenges. We do not offer treatments specific to prefrontal cortex dysfunction but our approach to mental health and wellbeing is informed by current research in neurobiology and cognitive function. We provide a supportive environment for individuals who want to improve their overall wellbeing.
Reviewed by: Dr. Emma Bardsley

Dr Emma Bardsley is a neuroscientist with a PhD from Oxford and a post doctorate from Auckland University, along with an undergraduate degree in Pharmacology from King’s College London. She has lectured extensively on neuroscience, physiology, and pharmacological interventions, bridging foundational research and its clinical applications. With a strong record of publications in high-impact journals and extensive experience in scientific writing, editing, and peer review, she excels at translating complex research into practical insights. Based in New Zealand and collaborating internationally, Emma is dedicated to advancing understanding and treatment in the fields of trauma, addiction, and recovery.
References
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